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背景資料

Thrombospondin-1 （TSP1） is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen， fibronectin， laminin， type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation， angiogenesis， and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors， including CD36， ?v integrins， ?1 integrins， syndecan， and integrin-associated protein （IAP or CD47）. It also interacts with various proteases involved in angiogenesis， including plasminogen， urokinase， matrix metalloproteinase， thrombin， cathepsin， and elastase. Positive and negative modulation of endothelial cell adhesion， motility， and growth are attributed to TSP1. Recently， thrombospondin-1 was found to bind to the reelin receptors， ApoER2 and VLDLR， in so doing affecting neuronal migration in the rostral migratory stream.

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來(lái)源宿主

昆蟲(chóng)Sf9細(xì)胞中重組表達(dá)

溶解建議

Sterile Filtered clear solution. The sterile protein solution contains 20mM Sodium phosphate， pH 6.0 and 300mM NaCl.

保存建議

Recombinant Human TSP should be stored between 2℃- 8℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。  生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白?？紤]到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。